Anti-Patched抗體,Patched/PTCH抗體相關產品：
Anti-5-HTR1B,5-羥色胺受體1B抗體
Anti-5-HTR2B 抗體
Anti-5-HTR2A 5-羥色胺受體2A抗體
Anti-5-HTT/SERT,5-羥色胺轉運蛋白抗體
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Anti-5-HTR4 5-羥色胺受體4抗體
Anti-5-LOX , 5-脂氧合酶抗體
Anti-8-OHdG,8-羥基脫氧鳥苷抗體
Anti-A2AR/Adenosine A2A-R,腺苷A2A受體抗體
Anti-AACT-α1, α-1抗胰*抗體
Anti-AAK1,AP2關聯激酶1抗體
Anti-AARS2,丙氨酰tRNA合成酶2抗體
Anti-AARS2 丙氨酰tRNA合成酶2抗體
Anti-AAT,α-1抗*抗體
Anti-AATK,細胞凋亡關聯*激酶抗體
Anti-Patched抗體,Patched/PTCH抗體Background: PTCH (Patched protein homolog 1) is a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). PTCH associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal.PTCH has a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. PTCH is expressed in the adult brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. It is also expressed in tumor cells but not in normal skin. During development PTCH is found in all major target tissues of sonic hedgehog, such as the ventral neural tube, somites, and tissues surrounding the zone of polarizing activity of the limb bud.
Defects in PTCH are probably the cause of basal cell nevus syndrome also known as Gorlin syndrome or Gorlin-Goltz syndrome
Anti-Patched抗體,Patched/PTCH抗體Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
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