動力蛋白激活蛋白1抗體,Anti-DCTN1抗體Background: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
Tissue specificity; Brain.
Involvement in disease; Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B); also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.
Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.
Defects in DCTN1 are the cause of Perry syndrome (PERRYS); also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally
動力蛋白激活蛋白1抗體,Anti-DCTN1抗體相關產品：
Anti-β-Amyloid抗體，β淀粉樣肽（1-16）抗體
Anti-β-Amyloid抗體，β淀粉樣肽（31-35）抗體
Anti-β-Amyloid抗體，β淀粉樣肽（1-28）抗體
Anti-β-Amyloid抗體，小鼠抗β淀粉樣肽（1-28）抗體
Anti-β-Amyloid抗體，β淀粉樣肽（25-35）抗體
Anti-β-Amyloid抗體，β淀粉樣肽（1-40）抗體
Anti-β-Amyloid 1-40/Aβ1-40抗體，β淀粉樣肽β-Amyloid 1-40/Aβ1-40 C端抗體
Anti-β-Amyloid 1-40（CT）mouse β淀粉樣肽 1-40 C端抗體
Anti-β-Amyloid（1-42）抗體，β淀粉樣肽（1-42）抗體
Anti-ANG-1抗體，血管生成素-1抗體
Anti-ANG-2 抗體，血管生成素-2抗體
Anti-Ankyrin G/ANK-3/抗體，錨定蛋白G抗體
Anti-ANP抗體，心鈉肽（心鈉素）抗體
Anti-AT2R抗體，血管緊張素Ⅱ-2型受體抗體
Anti-AT-Ⅱ抗體，血管緊張素II抗體
動力蛋白激活蛋白1抗體,Anti-DCTN1抗體別 名 Alternative names150 kDa dynein associated polypeptide; 150 kDa dynein-associated polypeptide; DAP 150; DAP-150; DAP150; DCTN 1; DCTN1; DCTN1_HUMAN; DP 150; DP-150; DP150; Dynactin 1 (p150 Glued (Drosophila) homolog); Dynactin 1 (p150 glued homolog Drosophila); Dynactin 1; Dynactin subunit 1; Dynactin1; HMN7B; P135; p150 Glued (Drosophila) homolog; p150 glued; p150 glued homolog; p150(GLUED) DROSOPHILA HOMOLOG OF; p150-glued; p150glued.
：021 60340850 021 60340830 021 60340820
客服 ：372584443 1091953152 827774711
