產品新聞

背景資料

Hepatitis B virus is the main cause for human liver disease， chronic infection frequently causes liver cancer and cirrhosis. The HBV core gene codes 2 distinct protein products， a 21.5-kDa protein being assembled to form nucleocapsid particles designated HBcAg， which wraps the viral DNA as well as the viral polymerase and RNase H， and a precore protein， designated as HBeAg， which is directly to the endoplasmic reticulum， processed at N- and C-terminally and secreted as non-particulate e-anitgen （HBeAg）. The pre-core protein contains an extra 29 N-terminal amino acids， serving as a signal peptide to direct the nascent polypeptide into secretory pathway. After the secretion， mature HBeAg is deleted at the residue 149 C-terminally and retains 10 precore residues N-terminally. HBcAg and HBeAg are distinctly recognized by antibodies but highly cross-reactive at the T-cell level.
The e antigen is found in the circulation， it is found during the active HBV infection， positive result indicates the risk for contagiousness， and is also used as indicator for the effectiveness of HBV treatment. Positive anti-HBeAg specifies an active stage of acute HBV infection that is in its final stages， the risk for contagiousness is dramatically reduced.

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來源宿主

大腸桿菌中重組表達

溶解建議

提供的重組丙型肝炎病毒e抗原產品為溶液形式.該產品已溶解在含2M 尿素的20mM 磷酸鈉緩沖液.

保存建議

Five years frozen. One month in solution at room temperature.

其他

ProSpec 是一家 著名細胞因子蛋白生產和研發的公司，具有20多年的生產經驗，專注于蛋白（重組及合成）生產研發。我們的核心產品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 生產工藝和規模使其可以提供毫克到克級蛋白，價格優于同類公司。絕大部分產品是天然成熟型蛋白，而不含有標簽蛋白?？紤]到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產品沒有添加保護劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產品為凍干粉，因此易于運輸和保存。